A short and convergent enantioselective synthesis of (3S)-2,3-oxidosqualene
1993; Elsevier BV; Volume: 34; Issue: 38 Linguagem: Inglês
10.1016/s0040-4039(00)61710-0
ISSN1873-3581
AutoresE. J. Corey, Mark C. Noe, Wen‐Chung Shieh,
Tópico(s)Natural product bioactivities and synthesis
ResumoA very useful synthesis of (3S)-2,3-oxidosqualene from geraniol, farnesol and E-1-bromo-4-chloro-3-methyl-2-butene is described which makes use of enantioselective and catalytic dihydroxylation of geranyl acetate and two E-stereospecific allylic coupling reactions mediated by E-prenylbarium reagents.
Referência(s)