HIV-1–induced AIDS in monkeys
2014; American Association for the Advancement of Science; Volume: 344; Issue: 6190 Linguagem: Inglês
10.1126/science.1250761
ISSN1095-9203
AutoresThéodora Hatziioannou, Gregory Q. Del Prete, Brandon F. Keele, Jacob D. Estes, Matthew W. McNatt, Julia Bitzegeio, Alice Raymond, Anthony B. Rodriguez, Fabian Schmidt, Charles M. Trubey, Jeremy Smedley, Michael Piatak, Vineet N. KewalRamani, Jeffrey D. Lifson, Paul D. Bieniasz,
Tópico(s)Immune Cell Function and Interaction
ResumoAdapting HIV-1 to infect monkeys, too HIV-1 replicates well in humans but not in monkeys or mice. On the up side, this reduces the risk of cross-species transmissions, but it makes the study of HIV-1 and AIDS more difficult. Hatziioannou et al. overcame this hurdle by serially passaging HIV-1 in pigtailed macaques. Over time, the HIV-1 acquired mutations that allowed it to adapt to the monkeys. Depleting CD8 + T cells during acute infection resulted in a subset of animals developing an AIDS-like disease by the fourth passage. HIV-1 envelope protein gene selection and the acquisition of mutations in the HIV protein Vpu, which allowed HIV-1 to overcome host restriction by the macaque protein tetherin, accompanied the viral adaptation to the monkeys. Science , this issue p. 1401
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