Immunogenetics and immunology of transplantation in Leiden
2014; Elsevier BV; Volume: 31; Issue: 4 Linguagem: Inglês
10.1016/j.trim.2014.09.009
ISSN1878-5492
AutoresSebastiaan Heidt, Michael Eikmans, Dave L. Roelen, Cees van Kooten, Frans H.J. Claas,
Tópico(s)Organ and Tissue Transplantation Research
ResumoThe historical observation of Jon van Rood that pregnancy can lead to the induction of HLA antibodies (1) was the start of a long history of research on immunogenetics and immunology of transplantation in Leiden. Some of the current research topics are presented in this mini-review. These include amongst others the differential immunogenicity of HLA mismatches in clinical transplantation, a special strategy to transplant highly sensitized patients, new tools to monitor donor specific memory B cells, new parameters for risk assessment in transplant recipients and the importance of the innate immune response in transplantation.
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