Mechanism of Action of Retinyl Compounds on Wound Healing III: Effect of Retinoic Acid Homologs on Granuloma Formation
1973; Elsevier BV; Volume: 62; Issue: 6 Linguagem: Inglês
10.1002/jps.2600620605
ISSN1520-6017
AutoresK. H. LEE, Cherng‐Chyi Fu, Michael R. Spencer, Theodore G. Tong, Richard Poon,
Tópico(s)Dyeing and Modifying Textile Fibers
ResumoAbstract A series of homologs of retinoic acid was synthesized. The activities of these compounds on granuloma formation induced by implanted cotton pellets were studied. The compound ( ß -C 22 acid) with two more carbons on the side chain of retinoic acid is the most active. The hexosamine and hydroxyproline contents in the granuloma affected by these compounds are also increased. The mechanisms of action of these compounds on wound healing are discussed.
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