Portal de Periódicos da CAPES

Evidence from the Resorbable-polymer stent versus Unresorbable-polymer stent Deployment for coronary Intervention: (RUDI-2) registry

2014; Elsevier BV; Volume: 172; Issue: 2 Linguagem: Inglês

10.1016/j.ijcard.2013.12.220

1874-1754

Gennaro Sardella, Carlo Briguori, Roberto Garbo, Enrico Romagnoli, Mauro Pennacchi, Michael Donahue, Giacomo Boccuzzi, Francesco Summaria, Giulia Conti, Emanuele Canali, Filippo Placentino, Rocco Edoardo Stio, Luigi Lucisano, Giuseppe Biondi‐Zoccai, Massimo Mancone, Francesco Fedele,

Cerebrovascular and Carotid Artery Diseases

Drug-eluting stents (DES) compared with bare-metal stents, reduce the rate of repeat revascularization [ [1] Stettler C. Wandel S. Allemann S. et al. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet. 2007; 370: 937-948 Abstract Full Text Full Text PDF PubMed Scopus (1283) Google Scholar ]. However, first-generation DES are associated with an increased risk of late stent thrombosis [ [2] Finn A.V. Joner M. Nakazawa G. et al. Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation. May 8 2007; 115: 2435-2441 Crossref PubMed Scopus (1140) Google Scholar ]. Several studies compared BES with PES and SES [ 3 Stefanini G.G. Kalesan B. Serruys P.W. et al. Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial. Lancet. Dec 3 2011; 378: 1940-1948 Abstract Full Text Full Text PDF PubMed Scopus (306) Google Scholar , 4 Byrne R.A. Kastrati A. Massberg S. et al. Biodegradable polymer versus permanent polymer drug-eluting stents and everolimus- versus sirolimus-eluting stents in patients with coronary artery disease: 3-year outcomes from a randomized clinical trial. J Am Coll Cardiol. Sep 20 2011; 58: 1325-1331 Abstract Full Text Full Text PDF PubMed Scopus (131) Google Scholar ] and with EES with different results [ 5 Smits P.C. Hofma S. Togni M. et al. Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): a randomised, controlled, non-inferiority trial. Lancet. Feb 23 2013; 381: 651-660 Abstract Full Text Full Text PDF PubMed Scopus (246) Google Scholar , 6 Christiansen E.H. Jensen L.O. Thayssen P. et al. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial. Lancet. Feb 23 2013; 381: 661-669 Abstract Full Text Full Text PDF PubMed Scopus (165) Google Scholar ]. Our purpose was to compare BES versus EES and ZES in a large real-world registry. RUDI 2 was a retrospective, observational, multicenter registry. Out of all population treated with DES, the study included all patients who implanted BES, EES and R-ZES at 4 high-volume centers between November 2008 and November 2011. From a total of 3505 initially shortlisted patients and excluding 295 subjects receiving a mixture of BES, EES or R-ZES, and 71 patients lost to follow-up, a total of 3139 subjects were included. Patients who received BES were 818 (26.1%), 1433 (45.7%) EES and 888 (28.3%) R-ZES. Baseline, procedural and long-term (>12 months) outcome data were entered into a prospectively maintained database. The primary end-point was the long-term rate of major adverse cardiac events (MACE). Moreover, we evaluated the incidence of bleeding according to TIMI classification. Secondary end-points were the rate of stent thrombosis. Information about short-term outcomes was obtained by records review. Clinical follow-up was achieved by phone call and/or direct visit and there was an independent event committee for event's adjudication. Computations were performed with SPSS 20. Differences between continuous variables were analyzed with ANOVA or Kruskal–Wallis test for non-parametric data. Differences between categorical variables were analyzed with the chi-squared test.