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A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996; American Association for the Advancement of Science; Volume: 273; Issue: 5277 Linguagem: Inglês

10.1126/science.273.5277.974

1095-9203

Andrew D. Howard, Scott D. Feighner, Doris Cully, Joseph P. Arena, Paul Liberator, Charles Rosenblum, Michel Hamelin, Donna L. Hreniuk, Oksana Palyha, Jennifer Anderson, Philip S. Paress, Carmen Dı́az, Michael F. Chou, Ken K. Liu, Karen K. McKee, Sheng‐Shung Pong, L Y Chaung, Alex Elbrecht, Mike Dashkevicz, R.P. Heavens, Mike Rigby, D.J.S. Sirinathsinghji, Dennis Dean, David G. Melillo, Arthur A. Patchett, Ravi P. Nargund, Patrick R. Griffin, Julie A. DeMartino, Sunil Gupta, James M. Schaeffer, Roy G. Smith, Lex H.T. Van der Ploeg,

Regulation of Appetite and Obesity

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.