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Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization

2000; Elsevier BV; Volume: 73; Issue: 3 Linguagem: Inglês

10.1016/s0015-0282(99)00585-3

1556-5653

I. Chilcott, R. Margara, Hannah Cohen, Raj Rai, Jonathan Skull, W. Pickering, Lesley Regan,

Liver Diseases and Immunity

Objective: To determine the prevalence of antiphospholipid (aPL) and anti-beta 2 glycoprotein I (anti-β2-GPI) antibodies in women referred for IVF and to prospectively evaluate the effect of these antibodies on IVF outcome.Design: Prospective observational study.Setting: A university hospital and IVF unit.Patient(s): Three hundred eighty consecutive women referred for IVF.Intervention(s): Blood samples taken before commencement of IVF cycles were tested for the presence of aPL (lupus anticoagulant [LA], anticardiolipin [aCL], and antiphosphatidyl serine antibodies [aPS]) and anti-β2-GPI antibodies.Main Outcome Measure(s): Antibody prevalence, pregnancy rates, and live birth rates.Result(s): Of the total 380 women, 89 tested persistently positive for aPL (23.4%). None of 176 women tested for IgG aPS antibodies had a positive titer. Only 3.3% (11 of 329) tested positive for anti-β2-GPI antibodies. Pregnancy rate, live birth rate, gestational age at delivery, and birth weight were not affected by aPL status.Conclusion(s): Although women referred for IVF have a high prevalence of aPL, these antibodies do not affect the outcome of treatment. Screening women undergoing IVF for aPL is not justified.