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Development of the zebrafish inner ear

2002; Wiley; Volume: 223; Issue: 4 Linguagem: Inglês

10.1002/dvdy.10073

1097-0177

Tanya T. Whitfield, Bruce B. Riley, Ming‐Yung Chiang, Bryan T. Phillips,

Congenital heart defects research

Abstract Abstract Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear. © 2002 Wiley‐Liss, Inc.