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Biodegradable delivery system for single step immunization with tetanus toxoid

1993; Elsevier BV; Volume: 93; Issue: 1-3 Linguagem: Inglês

10.1016/0378-5173(93)90188-l

1873-3476

Rajeev Singh Raghuvanshi, Manmohan Singh, G.P. Talwar,

Antimicrobial Peptides and Activities

Tetanus toxoid (TT) loaded biodegradable microspheres were prepared from poly(dl-lactide-co-glycolide) (monomer ratio 65:35) of Mol. Wt 75 000. The method of preparation was emulsification-solvent evaporation. In vitro vaccine release data are discussed. An in vivo immune response study was performed on rats. Results of immunization with the conventional schedule of TT and encapsulated TT until 5 months after immunization are presented, which were found to be comparable.