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Parathyroid Hormone-secreting Renal Carcinoma Associated with Hypercalcemia and Metabolic Alkalosis

1965; American College of Physicians; Volume: 63; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-63-5-858

1539-3704

ARTHUR S. O'GRADY,

Medical Imaging and Pathology Studies

Case Studies1 November 1965Parathyroid Hormone-secreting Renal Carcinoma Associated with Hypercalcemia and Metabolic AlkalosisARTHUR S. O'GRADY, M.B., LEONARD J. MORSE, M.D., JAMES B. LEE, M.D.ARTHUR S. O'GRADY, M.B.Search for more papers by this author, LEONARD J. MORSE, M.D.Search for more papers by this author, JAMES B. LEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-858 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypercalcemia without bone metastasis is an unusual systemic manifestation of neoplastic disease (1-22). In 1936, Gutman, Tyson, and Gutman (1) described a case of bronchogenic carcinoma with unexplained hypercalcemia which, aside from a localized area of Paget's disease, had normal bones at autopsy. Albright and Reifenstein (2, 3) subsequently described a case of renal carcinoma with a single pelvic metastasis and serum calcium and phosphorus values similar to those found in hyperparathyroidism. Irradiation of the pelvic metastasis transiently corrected the chemical abnormalities suggesting to them the possibility of a parathyroid hormone-secreting neoplasm. This theory was supported in 1956 by Plimpton...References1. GUTMANTYSONGUTMAN ABTLEB: Serum calcium inorganic phosphorus and phosphatase activity in hyperparathyroidism, Paget's disease, multiple myeloma and neoplastic disease of the bones. Arch. Intern. Med. (Chicago) 57: 379, 1936. CrossrefGoogle Scholar2. ALBRIGHTREIFENSTEIN FEC: The parathyroid glands and metabolic bone disease. The Williams & Wilkins Co., Baltimore, 1948, p. 92. Google Scholar3. Case records of the Massachusetts General Hospital (case number 27461). New Eng. J. Med. 225: 789, 1941. CrossrefGoogle Scholar4. 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FOURMANMCCONKEYSMITH PBJW: Defects of water reabsorption and hydrogen-ion excretion by the renal tubules in hyperparathyroidism. Lancet 278: 619, 1960. CrossrefGoogle Scholar41. NORDIN BE: The effect of intravenous parathyroid extract on urinary pH, bicarbonate and electrolyte excretion. Clin. Sci. 19: 311, 1960. MedlineGoogle Scholar42. HELLMANAUBARTTER DEWYFC: Evidence for a direct effect of parathyroid hormone on urinary acidification. Amer. J. Physiol. 209: 643, 1965. CrossrefMedlineGoogle Scholar43. SANDERSON PH: Hypercalcemia and renal failure in multiple secondary carcinoma of bone. Brit. Med. J. 2: 275, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARTHUR S. O'GRADY, M.B.; LEONARD J. MORSE, M.D.; JAMES B. LEE, M.D.Affiliations: Worcester, MassachusettsFrom the Metabolic Research Laboratory, St. Vincent Hospital, Worcester, Mass.This study was supported in part by a grant from the St. Vincent Research Foundation, St. Vincent Hospital, Worcester, Mass.Requests for reprints should be addressed to James B. Lee, M.D., St. Vincent Hospital, 25 Winthrop St., Worcester, Mass. 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