The anxiogenic action of benzodiazepine antagonists
1982; Elsevier BV; Volume: 21; Issue: 10 Linguagem: Inglês
10.1016/0028-3908(82)90118-6
ISSN1873-7064
AutoresSandra E. File, R. G. Lister, David Nutt,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoTwo benzodiazepine antagonists were tested in an animal model of anxiety, the social interaction test. Ethyl β-carboline-3-carboxylate (1 and 2 mg/kg) had a potent anxiogenic action; the imidazodiazepine RO 15-1788 (4–10 mg/kg) had a weak anxiogenic effect that with a larger dose (20 mg/kg) disappeared and RO 15-1788 (10 mg/kg) significantly counteracted the anxiogenic effect of the β-carboline (1 mg/kg). The implications of these results for the understanding of the pharmacological basis of anxiety and for the existence and nature of an endogenous ligand for the benzodiazepine binding site are discussed.
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