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Gold-Catalyzed Synthesis of Carbon-Bridged Medium-Sized Rings

2009; American Chemical Society; Volume: 11; Issue: 18 Linguagem: Inglês

10.1021/ol901722q

1523-7060

Francis Barabé, Geneviève Bétournay, Gabriel Bellavance, Louis Barriault,

Synthetic Organic Chemistry Methods

Bicyclo[m.n.1]alkenone frameworks possessing quaternary carbon centers adjacent to a bridged ketone are frequently found in bioactive natural products. Although several methods have been developed to construct such frameworks, most of them are specific to a particular scaffold. Herein, we report a mild and highly efficient method to generate carbon-bridged frameworks of various sizes using phosphino gold(I) catalysts.