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Priapism resulting from fluphenazine hydrochloride treatment reversed by diphenhydramine

1985; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês

10.1016/s0196-0644(85)80791-5

1097-6760

David A. Fishbain,

Hormonal and reproductive studies

A chronic schizophrenic patient received 30 mg fluphenazine hydrochloride (Prolixin®) PO and developed priapism. Urological examination and subsequent urological workup was negative, indentifying fluphenazine hydrochloride as the cause of the priapism. During the period of priapism evaluation, the patient developed a severe extrapyramidal reaction that was treated with diphenhydramine (Benadryl®) 50 mg IV push. There was remission of the extrapyramidal reaction in three minutes followed by resolution of the priapism. The rationale for the treatment of antipsychotic drug-induced priapism with anticholinergic drugs is discussed. A chronic schizophrenic patient received 30 mg fluphenazine hydrochloride (Prolixin®) PO and developed priapism. Urological examination and subsequent urological workup was negative, indentifying fluphenazine hydrochloride as the cause of the priapism. During the period of priapism evaluation, the patient developed a severe extrapyramidal reaction that was treated with diphenhydramine (Benadryl®) 50 mg IV push. There was remission of the extrapyramidal reaction in three minutes followed by resolution of the priapism. The rationale for the treatment of antipsychotic drug-induced priapism with anticholinergic drugs is discussed.