Portal de Periódicos da CAPES

Enantioselective Oxidation of Aldehydes Catalyzed by Alcohol Dehydrogenase

2012; Wiley; Volume: 51; Issue: 39 Linguagem: Inglês

10.1002/anie.201203219

1521-3773

Paul Könst, Hedda Merkens, Selin Kara, Svenja Kochius, Andreas Vogel, Ralf Zuhse, Dirk Holtmann, Isabel W. C. E. Arends, Frank Hollmann,

Metal-Catalyzed Oxygenation Mechanisms

Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.