Portal de Periódicos da CAPES

Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: An in vitro study

2011; Elsevier BV; Volume: 46; Issue: 10 Linguagem: Inglês

10.1016/j.ejmech.2011.07.044

1768-3254

Azmat Ali Khan, Mahboob Alam, Saba Tufail, Jamal Mustafa, Mohammad Owais,

Metabolomics and Mass Spectrometry Studies

Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol-PUFA esters have strong potential to emerge as effective anticancer agents.