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RACIAL DIFFERENCES IN PROSTATE ANDROGEN LEVELS IN MEN WITH CLINICALLY LOCALIZED PROSTATE CANCER

2004; Lippincott Williams & Wilkins; Volume: 171; Issue: 6 Part 1 Linguagem: Inglês

10.1097/01.ju.0000127739.88383.79

1527-3792

James L. Mohler, Kris E. Gaston, Dominic T. Moore, Michael J. Schell, Brian L. Cohen, Catharina M. Weaver, Peter Petrusz,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2004RACIAL DIFFERENCES IN PROSTATE ANDROGEN LEVELS IN MEN WITH CLINICALLY LOCALIZED PROSTATE CANCER JAMES L. MOHLER, KRIS E. GASTON, DOMINIC T. MOORE, MICHAEL J. SCHELL, BRIAN L. COHEN, CATHARINA WEAVER, and PETER PETRUSZ JAMES L. MOHLERJAMES L. MOHLER , KRIS E. GASTONKRIS E. GASTON , DOMINIC T. MOOREDOMINIC T. MOORE , MICHAEL J. SCHELLMICHAEL J. SCHELL , BRIAN L. COHENBRIAN L. COHEN , CATHARINA WEAVERCATHARINA WEAVER , and PETER PETRUSZPETER PETRUSZ View All Author Informationhttps://doi.org/10.1097/01.ju.0000127739.88383.79AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We sought to determine whether there are racial differences in androgenic stimulation within the prostate tissue microenvironment. Materials and Methods: Steroid hormones were extracted from snap frozen tissue obtained intraoperatively from radical prostatectomy specimens of 36 black and 59 white Americans. Testosterone, dihydrotestosterone (DHT), androstenedione (ASD), dehydroepiandrosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG) and prostate specific antigen (PSA) were measured using radioimmunoassay. The Wilcoxon 2 group test was performed to compare clinical characteristics and tissue steroid levels between white and black Americans. Nonparametric rank ANOVA was used to consider race and other clinical factors in a multivariable way. Results: Black and white American men were similar with respect to serum PSA, and pathological grade and stage. However, black men were younger (p = 0.01) and had a significantly higher body mass index (p = 0.02). Black and white men had similar testosterone and DHT. However, black men had higher ASD (p = 0.006) and SHBG (p = 0.009). Racial differences in ASD (p = 0.015) and SHBG (p = 0.008) persisted after controlling for age, body mass index, PSA, and pathological Gleason sum and stage. Conclusions: Tissue levels of testosterone and DHT did not differ by race. However, black men had higher tissue ASD and SHBG than white men. Higher tissue ASD did not result in a greater conversion of ASD to testosterone in the prostate of black men. Higher tissue SHBG may activate the androgen receptor through cyclic adenosine monophosphate dependent pathways. References 1 : Cancer statistics 2003. CA Cancer J Clin2003; 53: 5. Google Scholar 2 : SEER Cancer Statistics Review 1973–1998. Bethesda: National Cancer Institute2001. Google Scholar 3 : Serum testosterone levels in young black and white men. J Natl Cancer Inst1986; 76: 45. Google Scholar 4 : Racial/ethnic variations in male testosterone levels: a probable contributor to group differences in health. Steroids1992; 57: 72. 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Google Scholar From the Departments of Surgery (Division of Urology) (JLM, KEG, BLC), Pathology and Laboratory Medicine (JLM), Cellular and Developmental Biology (CW, PP) and Biostatistics (DTM, MJS) and University of North Carolina Lineberger Comprehensive Cancer Center (JLM, DTM, MJS), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, and Department of Urologic Oncology, Roswell Park Cancer Institute (JLM) and Department of Urology, State University of New York at Buffalo (JLM), Buffalo, New York© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByMohler J (2018) Editorial CommentJournal of Urology, VOL. 183, NO. 5, (1797-1797), Online publication date: 1-May-2010.Gulley J, Aragon-Ching J, Steinberg S, Hussain M, Sartor O, Higano C, Petrylak D, Chatta G, Arlen P, Figg W and Dahut W (2018) Kinetics of Serum Androgen Normalization and Factors Associated With Testosterone Reserve After Limited Androgen Deprivation Therapy for Nonmetastatic Prostate CancerJournal of Urology, VOL. 180, NO. 4, (1432-1437), Online publication date: 1-Oct-2008. Volume 171Issue 6 Part 1June 2004Page: 2277-2280 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.KeywordsandrogensEuropean continental ancestry groupprostateAfrican continental ancestry groupcontinental population groupsMetricsAuthor Information JAMES L. MOHLER More articles by this author KRIS E. GASTON More articles by this author DOMINIC T. MOORE More articles by this author MICHAEL J. SCHELL More articles by this author BRIAN L. COHEN More articles by this author CATHARINA WEAVER More articles by this author PETER PETRUSZ More articles by this author Expand All Advertisement PDF DownloadLoading ...