Discontinuation of imatinib therapy after achievement of complete molecular response in a Ph+ CML patient treated while in long lasting complete cytogenetic remission (CCR) induced by interferon
2006; Elsevier BV; Volume: 30; Issue: 12 Linguagem: Inglês
10.1016/j.leukres.2006.03.011
ISSN1873-5835
AutoresMassimo Breccia, Daniela Diverio, Fabrizio Pane, M. Nanni, Eleonora Russo, Francesca Biondo, Anna Maria Frustaci, Fabiana Gentilini, Giuliana Alimena,
Tópico(s)Eosinophilic Disorders and Syndromes
ResumoImatinib has become the gold standard therapy for Ph+ CML, as it induces complete cytogenetic remission (CCR) in 75–90% of patients in chronic phase (CP), and up to 40% of these patients obtain at least a 3 log reduction of BCR/ABL transcript [Kantarjian HM, Cortes JE, O’Brien S, Luthra R, Giles F, Verstovsek S, et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha. Blood. 2004;104:1979–1988]. However, it is not yet stated whether continued therapy is required to maintain this response or whether imatinib may be discontinued after confirmation of a prolonged complete molecular remission (CMR). We here report on a Ph+ CML case in long lasting CCR following interferon-alpha treatment (IFN) which reached CMR with imatinib but soon relapsed at molecular level after this latter drug discontinuation; we considered the present observation also in the light of previously reported data.
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