High throughput physicochemical profiling for drug discovery
2001; Elsevier BV; Volume: 90; Issue: 11 Linguagem: Inglês
10.1002/jps.1134
ISSN1520-6017
Autores Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoThe drug development bottlenecks of attrition and development time are being addressed by acquiring a profile of the candidate's physicochemical and physiological properties during early discovery phases. This information assists selection and optimization of pharmaceutical properties in parallel with activity. High throughput methods to measure the properties: solubility, permeability, lipophilicity, pKa, stability and integrity are described and compared in this article. The underlying discovery requirements, needs and application strategies are discussed. © 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:1838–1858, 2001
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