Facile conversion of epoxides to β-hydroxy nitriles under anhydrous conditions with lithium cyanide
1992; Elsevier BV; Volume: 33; Issue: 11 Linguagem: Inglês
10.1016/s0040-4039(00)91639-3
ISSN1873-3581
AutoresJames A. Ciaccio, Catherine Stanescu, Jongnic Bontemps,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoFunctionalized epoxides are easily and efficiently converted to β-hydroxy nitriles in good yield with high regio- and stereoselectivity upon treatment with lithium cyanide in refluxing anhydrous THF. The conditions described permit a one-pot conversion of epoxide to 1,3-amino alcohol via hydride reduction of the nitrile.
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