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Dimethylation of Adenine and the Resistance of Streptomyces erythraeus to Erythromycin

1982; Microbiology Society; Volume: 128; Issue: 10 Linguagem: Inglês

10.1099/00221287-128-10-2411

1465-2080

Richard Skinner, Eric Cundliffe,

Carbohydrate Chemistry and Synthesis

The erythromycin-producing organism, Streptomyces erythraeus, is highly resistant to erythromycin and also to other members of the macrolide, lincosamide and streptogramin type B (MLS) group of antibiotics. Resistance results from the presence of a single residue of N 6,N 6-dimethyl-adenine in S. erythraeus 23S rRNA. The enzyme which produces this residue (‘the erythromycin-resistance methylase’) has been isolated and characterized in vitro.