Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones
1998; Elsevier BV; Volume: 8; Issue: 12 Linguagem: Inglês
10.1016/s0960-894x(98)00261-3
ISSN1464-3405
AutoresSang‐Hun Jung, Hui-Soon Lee, Jae-Shin Song, Hwan-Mook Kim, Sang‐Bae Han, Chang‐Woo Lee, Moonsun Lee, Dong-Rack Choi, Jung‐Ah Lee, Yong‐Ho Chung, Sung‐June Yoon, Eun-Yi Moon, Hyun-Sook Hwang, Seung-Kyoo Seong, Dug-Keun Lee,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoNovel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
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