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Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines

2004; Elsevier BV; Volume: 12; Issue: 5 Linguagem: Inglês

10.1016/j.bmc.2003.12.026

1464-3391

Mavurapu Satyanarayana, Priti Tiwari, Brajendra K. Tripathi, Arvind K. Srivastava, Ram Pratap,

Genomics, phytochemicals, and oxidative stress

A series of aryloxypropanolamines (5a–r) of different chalcones (3a–e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models.