Enkephalin metabolism in brain and its inhibition
1982; Elsevier BV; Volume: 6; Issue: 4-6 Linguagem: Inglês
10.1016/s0278-5846(82)80166-8
ISSN1878-4216
AutoresJean‐Charles Schwartz, Sophie De La Baume, Chin-Cheng Yi, Pierre Chaillet, H Marçais-Collado, Jean Costentin,
Tópico(s)Protein Hydrolysis and Bioactive Peptides
ResumoVarious cerebral peptidases are able to hydrolyse the enkephalins into inactive fragments. Among these enzymes enkephalin-dipeptidylcarboxypeptidase ("enkephalinase") inhibited by thiorphan and a bestatin-sensitive aminopeptidase activity seem to play a key-role as "inactivating neuropeptidases". Their inhibition, in vitro as well as in vivo, leads to a protection of endogenous enkephalins and to antinociceptive effects.
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