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The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

2002; American Society for Microbiology; Volume: 76; Issue: 17 Linguagem: Inglês

10.1128/jvi.76.17.8973-8976.2002

1098-5514

Chelsea M. Byrd, Tove’ C. Bolken, Dennis E. Hruby,

Herpesvirus Infections and Treatments

ABSTRACT Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data were obtained to demonstrate that the I7L gene product and its encoded cysteine proteinase activity are responsible for vCPP activity.