Asymmetric Pictet-Spengler reactions employing amino acid esters as mediators of selectivity
1993; Elsevier BV; Volume: 34; Issue: 37 Linguagem: Inglês
10.1016/s0040-4039(00)73800-7
ISSN1873-3581
AutoresHerbert Waldmann, G. Schmidt, Martin Jansen, Jutta Geb,
Tópico(s)Synthesis and bioactivity of alkaloids
ResumoThe Pictet-Spengler cyclization of iminium salts generated in situ from N-(β-3-indolyl)ethyl substituted amino acid esters and differently substituted aldehydes proceeds with high stereoselectivity to deliver chiral tetrahydro-β-carbolines with diastereomer ratios up to 98.5:1.5.
Referência(s)