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Kinetics of triglyceride turnover of very low density lipoproteins of human plasma.

1965; American Society for Clinical Investigation; Volume: 44; Issue: 11 Linguagem: Inglês

10.1172/jci105290

1558-8238

Gerald M. Reaven, Daniell B. Hill, R. Gross, John W. Farquhar,

Diabetes, Cardiovascular Risks, and Lipoproteins

Ahrens and co-workers (1) have collated and extended prior observations (2-7) that high car- bohydrate, low fat diets may cause hypertriglyceridemia in certain subjects.They termed this phenomenon "carbohydrate-induced lipemia" (1).Despite uncertainties concerning the degree or duration of plasma triglyceride rise needed to merit this appellation, this general response to a high carbohydrate diet is frequently observed in patients with evidence for accelerated atherogenesis (1, 8-10).Furthermore, elevated plasma triglycerides are common in patients with "pre- mature" arteriosclerotic heart disease on ad libitum diets (11)(12)(13)(14)(15)(16).Consequently, it becomes im- portant to define the factors controlling plasma triglyceride concentration in man.It can be assumed that changes in concentra- tion of water soluble macromolecules confined to the plasma space, such as lipoproteins, result from variations in rates of entry into and re- moval from plasma, or both.Hypertriglyceridemia in patients with "fat-induced lipemia," another and a relatively uncommon syndrome (1,