Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
1998; Wiley; Volume: 429; Issue: 2 Linguagem: Inglês
10.1016/s0014-5793(98)00585-7
ISSN1873-3468
AutoresTakashi Sekine, Seok Ho, Minoru Tsuda, Nopporn Apiwattanakul, Noriko Nakajima, Yoshikatsu Kanai, Hitoshi Endou,
Tópico(s)Ion Transport and Channel Regulation
ResumoIn the present study, we demonstrate that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity to that of the renal multispecific organic anion transporter, OAT1. When expressed in Xenopus laevis oocytes, NLT mediated uptake of organic anions, such as salicylate, acetylsalicylate, PGE 2 , dicarboxylates and p ‐aminohippurate. [ 14 C]Salicylate uptake via NLT was saturable ( K m =88.8±23.4 μM) and sodium‐independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver≫kidney). We propose that NLT be renamed OAT2.
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