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Retinoblastoma and Chromosome Abnormality

1974; American Medical Association; Volume: 92; Issue: 6 Linguagem: Inglês

10.1001/archopht.1974.01010010504007

1538-3601

Rufus O. Howard,

Polyomavirus and related diseases

A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.