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Disposition and Clearance of Tungsten after Single-dose Oral and Intravenous Exposure in Rodents

2007; Taylor & Francis; Volume: 70; Issue: 10 Linguagem: Inglês

10.1080/15287390701211762

1087-2620

Jacob D. McDonald, Waylon Weber, Rena Marr, Dean Kracko, Hnin Khain, R. Arimoto,

Air Quality and Health Impacts

Abstract Tungsten (W) has been nominated for study to the National Toxicology Program (NTP) because of reported associations between concentrations of W in drinking water and childhood leukemia. The disposition of W (administered as sodium tungstate dihydrate in water) in plasma, liver, kidneys, uterus, femur, and intestine of rodents (Sprague-Dawley rats and C57BL/6N mice) was characterized after exposures by oral gavage (1, 10, or 100 mg/kg) or intravenous (1 mg/kg) administration. Each tissue (or plasma) was collected and analyzed by inductively coupled plasma mass spectrometry at 1, 2, 4, or 24 h after dose administration. W was observed in plasma and all tissues after both gavage and iv administration. In rats, concentrations in plasma and most tissues peaked at 4 h. In mice, concentrations in plasma and most tissues peaked at 1 h. Although the amount of W in each matrix decreased significantly by 24 h, there was W remaining in several tissues, especially at the higher doses. This work was supported by contract N01-ES-25483 from the National Institute of Environmental Health Sciences (NIEHS). We thank Dr. L. T. Burka at NIEHS for his critical review of the article.