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Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.

1989; Japanese Pharmacological Society; Volume: 51; Issue: 2 Linguagem: Inglês

10.1254/jjp.51.299

1347-3506

Akinobu Nagaoka, Masaki Shibota,

Neuroscience and Neuropharmacology Research

Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (3 mg/kg). These results suggest that manidipine may be useful for treating hypertension.