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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

2011; American Chemical Society; Volume: 55; Issue: 2 Linguagem: Inglês

10.1021/jm2014748

1520-4804

Matthew F. Brown, Usa Reilly, J. A. Abramite, Joel T. Arcari, Robert M. Oliver, Rose A. Barham, Ye Che, Jinshan Michael Chen, Elizabeth M. Collantes, Seung Won Chung, Charlene Desbonnet, Jonathan L. Doty, Matthew Doroski, Juntyma J. Engtrakul, Thomas M. Harris, Michael D. Huband, John D. Knafels, Karen L. Leach, Shenping Liu, Anthony Marfat, Andrea Marra, Eric B. McElroy, Michael Melnick, Carol A. Menard, Justin I. Montgomery, Lisa Mullins, Mark C. Noe, John P. O’Donnell, Joseph Penzien, Mark S. Plummer, Loren Price, Veerabahu Shanmugasundaram, Christy L. Thoma, Daniel P. Uccello, Joseph S. Warmus, Donn G. Wishka,

Pneumocystis jirovecii pneumonia detection and treatment

In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.