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Two Common Gene Variants on Chromosome 9 and Risk of Atherothrombosis

2007; Lippincott Williams & Wilkins; Volume: 38; Issue: 10 Linguagem: Inglês

10.1161/strokeaha.107.497669

1524-4628

Robert Y.L. Zee, Paul M. Ridker,

Nuclear Receptors and Signaling

HomeStrokeVol. 38, No. 10Two Common Gene Variants on Chromosome 9 and Risk of Atherothrombosis Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBTwo Common Gene Variants on Chromosome 9 and Risk of Atherothrombosis Robert Y.L. Zee and Paul M Ridker Robert Y.L. ZeeRobert Y.L. Zee The Center for Cardiovascular Disease Prevention, The Donald W. Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass and Paul M RidkerPaul M Ridker The Center for Cardiovascular Disease Prevention, The Donald W. Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass Originally published23 Aug 2007https://doi.org/10.1161/STROKEAHA.107.497669Stroke. 2007;38:e111Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: August 23, 2007: Previous Version 1 To the Editor:McPherson et al recently reported (in the journal Science) the association of 2 single nucleotide polymorphisms (rs10757274 and rs2383206) with coronary heart disease (CHD).1 After their report, we examined the possible association of these 2 gene variants with atherothrombotic events using a prospective, nested, matched case-control design among initially healthy US white men participating in the Physicians' Health Study. The baseline characteristics of the sample participants used have been described elsewhere.2,3 Genotypes were determined on 335 myocardial infarction (MI) case-control pairs, and 254 ischemic stroke (IsST) case-control pairs; all matched on age ±2 years, smoking status, and time of follow-up. Our observed allele frequencies were similar to those reported by McPherson et al: the rs10757274 G-allele frequencies were 0.467, 0.430, 0.508, and 0.506 for MI-controls, MI-cases, IsST-controls, and IsST-cases, respectively; and the rs2383206 G-allele frequencies were 0.565, 0.599, 0.537, and 0.534 for MI-controls, MI-cases, IsST-controls, and IsST-cases, respectively. Overall, we found little evidence of association between the rs10757274 variant and incident MI or IsST (Table). By contrast, although statistically nonsignificant, the magnitude and direction of the effect estimate for rs2383206 with risk of MI were similar to the CHD risk estimates reported by McPherson et al. These data highlight the complexity of genetic association studies designed to dissect heritable patterns in common human disorders. Table. Conditional Logistic Regression AnalysisMIIsSTCrudeAdjustedCrudeAdjustedOR indicates odds ratio; Crude; conditional on age, smoking status and time of follow-up; Adjusted, further adjusting for randomized treatment assignment, BMI, history of hypertension, and presence or absence of diabetes.VariantOR; 95% CI; POR; 95% CI; POR; 95% CI; POR; 95% CI; Prs10757274 AAReference……… AG0.840; 0.580–1.217; 0.360.765; 0.511–1.145; 0.190.949; 0.599–1.503; 0.821.046; 0.644–1.697; 0.86 GG0.723; 0.457–1.144; 0.170.645; 0.392–1.062; 0.081.029; 0.619–1.712; 0.911.157; 0.668–2.003; 0.60rs2383206 AAReference……… AG1.127; 0.737–1.724; 0.581.106; 0.706–1.735; 0.661.093; 0.691–1.727; 0.701.005; 0.614–1.646; 0.98 GG1.303; 0.831–2.045; 0.251.449; 0.895–2.347; 0.130.909; 0.550–1.501; 0.710.842; 0.490–1.449; 0.53Sources of FundingSupported by grants from the National Heart Lung and Blood Institute (HL-58755, and HL-63293), the Doris Duke Charitable Foundation, the American Heart Association, the Donald W. Reynolds Foundation, Las Vegas, Nevada, and the Leducq Foundation, Paris, France.DisclosuresNone.1 McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316: 1488–1491.CrossrefMedlineGoogle Scholar2 Zee RY, Cheng S, Hegener HH, Erlich HA, Ridker PM. Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke. 2006; 37: 2007–2011.LinkGoogle Scholar3 Hegener HH, Lee IM, Cook NR, Ridker PM, Zee RY. Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. Clin Chem. 2006; 52: 2021–2027.CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Tan C, Liu J, Wei J and Yang S (2019) Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis , Bioscience Reports, 10.1042/BSR20182127, 39:5, Online publication date: 31-May-2019. Bozpolat A, Unal E, Topaloglu T, Taheri S, Bayram A, Ozcan A, Karakukcu M, Ozdemir M and Per H (2019) The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes, Journal of Thrombosis and Thrombolysis, 10.1007/s11239-018-01802-9, 47:4, (578-584), Online publication date: 1-May-2019. Yue X, Tian L, Fan X, Xu G, Shi F and Liu X (2015) Chromosome 9p21.3 Variants Are Associated with Cerebral Infarction in Chinese Population, Journal of Molecular Neuroscience, 10.1007/s12031-015-0494-9, 56:3, (546-552), Online publication date: 1-Jul-2015. Helgeland Ø, Hertel J, Molven A, Ræder H, Platou C, Midthjell K, Hveem K, Nygård O, Njølstad P and Johansson S (2015) The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey), International Journal of Endocrinology, 10.1155/2015/164652, 2015, (1-9), . Ni X, Zhang J and Ross O (2014) Association between 9p21 Genomic Markers and Ischemic Stroke Risk: Evidence Based on 21 Studies, PLoS ONE, 10.1371/journal.pone.0090255, 9:3, (e90255) Gioli-Pereira L, Santos P, Ferreira N, Hueb W, Krieger J and Pereira A (2012) Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21, BMC Cardiovascular Disorders, 10.1186/1471-2261-12-61, 12:1, Online publication date: 1-Dec-2012. Zhang W, Chen Y, Liu P, Chen J, Song L, Tang Y, Wang Y, Liu J, Hu F and Hui R (2011) Variants on Chromosome 9p21.3 Correlated With ANRIL Expression Contribute to Stroke Risk and Recurrence in a Large Prospective Stroke Population, Stroke, 43:1, (14-21), Online publication date: 1-Jan-2012. Lin H, Tsai P, Liao Y, Lin T, Tai C, Juo S and Lin R (2023) Chromosome 9p21 Genetic Variants are Associated with Myocardial Infarction but Not with Ischemic Stroke in a Taiwanese Population, Journal of Investigative Medicine, 10.2310/JIM.0b013e318214ea49, 59:6, (926-930), Online publication date: 1-Aug-2011. Koch W, Türk S, Erl A, Hoppmann P, Pfeufer A, King L, Schömig A and Kastrati A (2011) The chromosome 9p21 region and myocardial infarction in a European population, Atherosclerosis, 10.1016/j.atherosclerosis.2011.03.014, 217:1, (220-226), Online publication date: 1-Jul-2011. (2009) Genomewide Association Studies of Stroke, New England Journal of Medicine, 10.1056/NEJMc091089, 361:7, (722-722), Online publication date: 13-Aug-2009. Yamagishi K, Folsom A, Rosamond W and Boerwinkle E (2009) A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study, European Heart Journal, 10.1093/eurheartj/ehp087, 30:10, (1222-1228), Online publication date: 2-May-2009. Gschwendtner A, Bevan S, Cole J, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E, Mitchell B, Furie K, Slowik A, Rich S, Syme P, MacLeod M, Meschia J, Rosand J, Kittner S, Markus H, Müller-Myhsok B and Dichgans M (2009) Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke, Annals of Neurology, 10.1002/ana.21590, 65:5, (531-539), Online publication date: 1-May-2009. Wahlstrand B, Orho-Melander M, Delling L, Kjeldsen S, Narkiewicz K, Almgren P, Hedner T and Melander O (2009) The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension, Journal of Hypertension, 10.1097/HJH.0b013e328326f7eb, 27:4, (769-773), Online publication date: 1-Apr-2009. DI CASTELNUOVO A, PEZZINI A, LATELLA M, LICHY C and IACOVIELLO L (2009) Polymorphisms in chromosome 9 and risk of ischemic stroke in two European white populations, and a meta‐analysis, Journal of Thrombosis and Haemostasis, 10.1111/j.1538-7836.2008.03237.x, 7:2, (365-367), Online publication date: 1-Feb-2009. October 2007Vol 38, Issue 10 Advertisement Article InformationMetrics https://doi.org/10.1161/STROKEAHA.107.497669PMID: 17717303 Originally publishedAugust 23, 2007 PDF download Advertisement