Portal de Periódicos da CAPES

An Apigenin-Derived Xanthine Oxidase Inhibitor from Palhinhaea c ernua

2006; American Chemical Society; Volume: 69; Issue: 7 Linguagem: Inglês

10.1021/np060038a

1520-6025

Rui Jiao, Hui Ming Ge, Da Hua Shi, Ren Xiang Tan,

Traditional and Medicinal Uses of Annonaceae

Fractionation of the ethanol extract of Palhinhaea cernua afforded a new (1) and two known p-coumaroylated apigenin glycosides (2, 3) in addition to dillenetin, rhamnazin, α-onocerin, β-sitosterol, and (E)-2-hydroxy-5-methoxycinnamic acid. The structure of compound 1 was elucidated as apigenin-4'-O-(2' '-O-p-coumaroyl)-β-d-glucopyranoside by a combination of its spectroscopic data. The new glycoside 1 inhibits xanthine oxidase (IC50: 23.95 ± 0.43 μM) in a competitive−noncompetitive manner with Ki and KI values of 14.35 and 93.68 μM, whereas compounds 2 and 3 were inactive. The distribution and significance of acylated flavonoid glycosides are discussed.