Concentrations of amyloid-β protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease
1994; Elsevier BV; Volume: 172; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(94)90677-7
ISSN1872-7972
AutoresWillem A. van Gool, Dale B. Schenk, Pieter A. Bolhuis,
Tópico(s)Dementia and Cognitive Impairment Research
ResumoCerebral deposition of amyloid-beta protein (A beta) is central to the pathogenesis of Alzheimer's disease (AD). Increasing age is one of the few definitively established risk factors for this disease. The concentration of A beta was measured in cerebrospinal fluid (CSF) with a sensitive enzyme-linked immunosorbent assay in 18 adult neurological patients free from neurodegenerative disease. CSF A beta increased with age, yielding a significant correlation of 0.84. This observation suggests that increased levels of A beta in CSF may be an index of age-related changes in the processing of the amyloid-beta precursor protein resulting in an increased risk for AD.
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