Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex
1994; Elsevier BV; Volume: 168; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(94)90437-5
ISSN1872-7972
AutoresPaul Berger, Kevin Farrel, Frank R. Sharp, P. Skolnick,
Tópico(s)Ion channel regulation and function
ResumoThe potential for compounds acting at the strychnine-insensitive glycine receptor to injure neurons was examined using induction of a 70 kDa heat shock protein (HSP-70) as a marker. HSP-70 was consistently detected in retrosplenial and cingulate cortices after MK-801 but not glycine drug treatment. Elsewhere in the cortex, mild diffuse HSP-70 immunoreactivity was detected following 7-chlorokynurenic acid. Following HA-966, intense hippocampal HSP-70 immunoreactivity was observed. These findings indicate that even after very high doses, drugs acting at the strychnine-insensitive glycine receptor are less likely to injure cingulate cortical neurons than other classes of NMDA antagonists.
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