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Artigo Revisado por pares
BIBTEX RIS

Rhodium-Catalyzed [3 + 2] Annulation of Indoles

2009; American Chemical Society; Volume: 132; Issue: 2 Linguagem: Inglês

10.1021/ja9078094

ISSN

1943-2984

Autores

Yajing Lian, Huw M. L. Davies,

Tópico(s)

Asymmetric Synthesis and Catalysis

Resumo

An effective Rh(2)(S-DOSP)(4)-catalyzed asymmetric cyclopentannulation of indolyl rings has been developed. Depending on the substitution pattern of the indole, two distinct regioisomeric products can be generated. These studies demonstrate that rhodium-catalyzed reactions of donor/acceptor carbenoids proceeding by means of zwitterionic intermediates can be carried out with very high asymmetric induction.

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