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Elevated serum concentrations of IgE antibodies to environmental antigens in HIV-seropositive male homosexuals

1990; Elsevier BV; Volume: 86; Issue: 6 Linguagem: Inglês

10.1016/s0091-6749(05)80149-6

1097-6825

Sally Sample, David Chernoff, Gail A. Lenahan, M Serwońska, Setu P. Rangi, Jeffrey W. Sherman, Charles D. Sooy, Harry Hollander, Edward J. Goetzl,

Herpesvirus Infections and Treatments

Forty-five homosexual male subjects with human immunodeficiency virus (HIV) infection, who received care during a 4-month period in an ambulatory center for acquired immunodeficiency syndrome (AIDS), were classified according to their principal presentation with characteristic secondary infections (CDC group IV C, N = 28), cancers (IV D, N = 10), or limited or no symptoms (groups H, III, IV A, or 1V B, N = 7).The incidence of allergic rhinitis and conjunctivitis increased after H1V seroconversion by approximately twofold in patients of groups IV C and IV D. The mean serum concentration of lgE was significantly higher for group IV C than for the other HIV-seropositive groups and for a control group of 45 H1V-seronegative homosexual male subjects from the same community who were studied concurrently.More patients in groups IV C and IV D had positive RASTs for a panel of environmental antigens than patients in the other HIV-seropositive groups and the HIV-seronegative control group.Patients with AIDS presenting with typical secondary infections thus have a high frequency of some clinical and laboratory manifestations of allergic diseases.(