Artigo Revisado por pares

Generalized melanosis secondary to malignant melanoma.Report of a case with serum and tissue tyrosinase studies

1969; Wiley; Volume: 24; Issue: 5 Linguagem: Inglês

10.1002/1097-0142(196911)24

ISSN

1097-0142

Autores

Norman Sohn, Stephen L. Gumport, Heinrich Gang, Menek Goldstein, Ludwig M. Deppisch,

Tópico(s)

Skin Protection and Aging

Resumo

A case of generalized melanosis secondary to malignant melanoma is described. The tyrosinase activity of serum and tissues from this patient has been measured. The first 2 steps of melanogenesis (tyrosine → dopa and dopa → dopachrome) have been separately assayed. Serum and homogenates from skin and spleen showed the highest activity in both steps. Weak activity was detected in vagina and lung, but no activity was detected in the adrenals, kidney, liver, and rectum. An endogenous compound which inhibits the enzymic activity as well as the auto-oxidation of dopa is found to be present in almost all of the tissues analyzed. Tyrosinase activity was not found in serum samples from control patients without malignant melanoma nor from other patients with malignant melanoma without generalized melanosis. Inhibition of tyrosinase activity by endogenous substances, however, was present in all serum samples analyzed.

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