Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Spontaneous Cytokine Production in Children According to Biological Characteristics and Environmental Exposures

2009; National Institute of Environmental Health Sciences; Volume: 117; Issue: 5 Linguagem: Inglês

10.1289/ehp.0800366

ISSN

1552-9924

Autores

Camila Alexandrina Figueiredo, Neuza Maria Alcântara‐Neves, Rafael Veiga, Leila Denise Alves Ferreira Amorim, Vitor Camilo Cavalcante Dattoli, Lívia Ribeiro Mendonça, Samuel B Junqueira, Bernd Genser, Mariese Conceição Alves dos Santos, Lain Carlos Pontes de Carvalho, Philip J. Cooper, Laura C. Rodrigues, Maurício L. Barreto,

Tópico(s)

Immune responses and vaccinations

Resumo

BackgroundEnvironmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma.ObjectiveThis study was designed to investigate the effects of environmental exposures on the cytokine profile of children.MethodsThe study involved measurement of T helper (Th) 1 (interferon-gamma), 2 [interleukin (IL)-5 and IL-13], and the regulatory cytokine IL-10 in unstimulated peripheral blood leukocytes from 1,376 children 4–11 years of age living in a poor urban area of the tropics. We also assessed the impact of environmental exposures in addition to biological characteristics recorded at the time of blood collection and earlier in childhood (0–3 years before blood collection).ResultsThe proportion of children producing IL-10 was greater among those without access to drinking water [p < 0.05, chi-square test, odds ratio (OR) = 1.67]. The proportion of children producing IL-5 and IL-10 (OR = 10.76) was significantly greater in households that had never had a sewage system (p < 0.05, trend test).ConclusionsThese data provide evidence for the profound effects of environmental exposures in early life as well as immune homeostasis in later childhood. Decreased hygiene (lack of access to clean drinking water and sanitation) in the first 3 years of life is associated with higher spontaneous IL-10 production up to 8 years later in life.

Referência(s)