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Diagnostically Confusing Complications of Diphenylhydantoin Therapy

1963; American College of Physicians; Volume: 59; Issue: 6 Linguagem: Inglês

10.7326/0003-4819-59-6-914

1539-3704

Marshall Sparberg,

Plant-based Medicinal Research

Review1 December 1963Diagnostically Confusing Complications of Diphenylhydantoin TherapyA ReviewMARSHALL SPARBERG, M.D.MARSHALL SPARBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-914 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiphenylhydantoin (DPH) (Dilantin®) has been widely used in the therapy of grand mal and psychomotor epilepsy since 1938 (1). The common complications were recognized early (2, 3). Cerebellar incoordination is the most frequent neurologic complication, but other diagnostically confusing neurologic lesions may occur, such as hemiplegia (4), extraocular palsy (5), and meningeal irritation with pleocytosis and elevated protein in the cerebrospinal fluid (6). Gingival hyperplasia, due to excessive deposition of collagen, has been observed in 6 to 62 per cent of patients receiving DPH (7). 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Author, Article, and Disclosure InformationAuthors: MARSHALL SPARBERG, M.D.Affiliations: Chicago, IllinoisFrom Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.Requests for reprints should be addressed to Marshall Sparberg, M.D., 1121 Skokie Ridge Drive, Glencoe, Illinois. 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LUDWIG, M.D., F.A.C.P., LOUIS B. CHAYKIN, M.D., ANTONIO V. ESCUETA, M.D.Electroencephalographic findings in a case of acute reaction to dilantinFindings suggestive of systemic lupus erythematosus in subjects on chronic anticonvulsant therapyDiphenylhydantoin Sodium in Cardiac ArrhythmiasDiphenylhydantoin-induced hypersensitivity reactionSOME OBSERVATIONS ON SURGICAL HYPOTHERMIA BY MEANS OF EXTENSIVE RADIANT COOLINGDRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES 1 December 1963Volume 59, Issue 6Page: 914-930KeywordsFolic acidLeukocytosisLymphomaMegaloblastic anemiaNauseaParalysisProteinsSaltsSarcomaThyroid ePublished: 1 December 2008 Issue Published: 1 December 1963 PDF downloadLoading ...