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Nucleotide and deduced amino acid sequence of human ribosomal protein L18

1993; Elsevier BV; Volume: 1216; Issue: 1 Linguagem: Inglês

10.1016/0167-4781(93)90050-n

1879-2634

Mark Puder, Graham F. Barnard, Raymond J. Staniunas, Glenn Steele, Lan Bo Chen,

RNA modifications and cancer

Ribosomal protein L18 mRNA is overexpressed in human colorectal cancer compared to normal colon tissue. We report the nucleotide sequence of human L18 cDNA derived from a normal colon source. There were no mutational changes in segments of L18 cDNA derived from two tumor sources. The L18 cDNA was 690 base pairs long and predicts a single open reading frame of 564 nucleotides, encoding 188 amino acids with a M(r) = 21,621, it is homologous to rat L18 and Xenopus laevis L14.