Portal de Periódicos da CAPES

Critical Evaluation of the Compactor

1966; Elsevier BV; Volume: 55; Issue: 3 Linguagem: Inglês

10.1002/jps.2600550312

1520-6017

R. Cohn, Hans G. H. J. Heilig, A. Delorimier,

Injection Molding Process and Properties

With the assistance of a suitably prepared experimental design a compactor was optimized to prepare a basic granulation to which other drugs could be added and directly compressed into tablets. An IBM 1620 computor was employed to evaluate the data and to extrapolate additional information for the preparation of contour charts. The contour charts permitted a simple and accurate interpretation of the data and allowed selection of a set of optimum processing conditions. Additional trials confirmed the reliability of this technique. With the assistance of a suitably prepared experimental design a compactor was optimized to prepare a basic granulation to which other drugs could be added and directly compressed into tablets. An IBM 1620 computor was employed to evaluate the data and to extrapolate additional information for the preparation of contour charts. The contour charts permitted a simple and accurate interpretation of the data and allowed selection of a set of optimum processing conditions. Additional trials confirmed the reliability of this technique.