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Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials

2014; Informa; Volume: 26; Issue: 4 Linguagem: Inglês

10.3109/09546634.2014.991268

1471-1753

Yan Sun, Yan Wu, Bihuan Xiao, Lu Li, Li Li, Hong‐Duo Chen, Xing‐Hua Gao,

Acne and Rosacea Treatments and Effects

Background: Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo. Objective: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo. Methods: Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo". Results: Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable. Conclusions: The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.