Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome
1997; Elsevier BV; Volume: 131; Issue: 1 Linguagem: Inglês
10.1016/s0022-3476(97)70139-2
ISSN1097-6833
AutoresRohan Ameratunga, Howard M. Lederman, Kathleen E. Sullivan, Hans D. Ochs, Kuniaki Seyama, J. French, Ross L. Prestidge, J. Marbrook, William C. Fanslow, Jerry A. Winkelstein,
Tópico(s)Immune Cell Function and Interaction
ResumoAbstract We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii. (J Pediatr 1997;131:147-50)
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