An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds
2001; Portland Press; Volume: 353; Issue: 3 Linguagem: Inglês
10.1042/0264-6021
ISSN1470-8728
AutoresSerge Raimbault, Sami Dridi, Frédérique Denjean, Joël Lachuer, Elodie Couplan, Frédéric Bouillaud, A Bordas, Claude Duchamp, Mohammed Taouis, Daniel Ricquier,
Tópico(s)Physiological and biochemical adaptations
ResumoThe cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46% identical with mammalian UCP1, UCP2 and UCP3 and plant UCP respectively. avUCP mRNA expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis, and 3.6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure.
Referência(s)