Portal de Periódicos da CAPES

mTOR and the control of whole body metabolism

2009; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês

10.1016/j.ceb.2009.01.024

1879-0410

Pazit Polak, Michael N. Hall,

Cancer, Hypoxia, and Metabolism

Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that functions as part of two distinct multiprotein complexes to regulate growth and metabolism. This review describes the most important recent advances in the mTOR signaling field. In addition, we provide an overview on the functions of mTOR in different organs, with a special focus on the role of mTOR in whole body energy metabolism.