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Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety

2007; Elsevier BV; Volume: 17; Issue: 19 Linguagem: Inglês

10.1016/j.bmcl.2007.08.021

1464-3405

V. Tomar, G. Bhattacharjee, Kamaluddin Kamaluddin, Ashok Kumar,

Fungal Plant Pathogen Control

Two new series of chalcones have been synthesized by reacting 1-(4-piperazin-1-yl-phenyl)ethanone and 1-(2,5-dichloro-3-thienyl)-1-ethanone with different substituted benzaldehydes in turn by Claisen–Schmidt condensation. The compounds have been characterized by IR, 1H NMR spectral and microanalysis data. All the synthesized compounds have been evaluated for antimicrobial activity. Some of these derivatives are potentially active against Gram-positive bacteria, Staphylococcus aureus and Escherichia coli while the most potent compound (1) in this study showed MIC50 value of 2.22 μg/mL against Candida albicans.