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Thrombophilia: An Update

2007; Thieme Medical Publishers (Germany); Volume: 33; Issue: 6 Linguagem: Inglês

10.1055/s-2007-985752

1098-9064

Saskia Middeldorp, Marcel Levi,

Hemophilia Treatment and Research

This issue of Seminars in Thrombosis and Hemostasis is dedicated to inherited thrombophilia. The various clinical manifestations and implications for testing are discussed in different articles. Furthermore, animal models that are being used to study thrombophilia are discussed. Thrombophilia is defined as a disorder associated with an increased tendency to venous thromboembolism (VTE).[1] Thrombophilia can be acquired (such as in patients with cancer) or congenital, in which case a defect in the coagulation system is inherited. The term thrombophilia was introduced as a MeSH (Medical Subject Headings) term in 1998, and using this as a search term in the PubMed database at present yields more than 16,500 publications, of which the vast majority is related to inherited forms of this condition. This introduction provides a short overview of thrombophilia, with an emphasis on topics that will not be covered in the reviews in this issue.