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Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

2006; Elsevier BV; Volume: 31; Issue: 4 Linguagem: Inglês

10.1016/j.neuroimage.2006.02.038

1095-9572

Topun Austin, Adam Gibson, Gilberto Branco, Rozarina Md. Yusof, Simon Arridge, Judith Meek, J S Wyatt, David T. Delpy, Jeremy C. Hebden,

Hemodynamic Monitoring and Therapy

Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside.