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Dermatitis herpetiformis: a review of 119 cases

1983; Oxford University Press; Volume: 8; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2230.1983.tb01815.x

1365-2230

Dan Buckley, J S English, Willie Molloy, C. T. Doyle, M. J. Whelton,

Eosinophilic Disorders and Syndromes

Between 1954 and 1980 119 cases of dermatitis herpetiformis have been seen. IgA examination of uninvolved skin was positive in 93·6%, of patients. Jejunal biopsy showed villous atrophy in 6%, of patients. HLA typing showed HLA-B8 present in 83·7%, HLA-Ai in 74·4%, and HLA-B8 or -Ai in 93%, of patients. Antinuclear factor was present in 19%, thyroid antibodies in 6%, and parietal cell antibodies in 8%, of the patients. Two out of twenty patients (10%) examined had anti-reticulin antibodies. Twenty per cent of the patients had a positive family history of atopy, and 6%, had a positive personal history of it. Fourteen patients (11-7%) had relatives with coeliac disease. A gluten-free diet is advocated for all patients. Dapsone will control the rash if patients are unwilling to take the diet.